Antidepressant and Anti - Anxiety Effect of Ellagic Acid from Punica granatum L . Rind in Olfactory Bulbectomy Model in Rats

The present study evaluated the anti-depressant and antianxiety effect of standardized extract of Punica granatum (HEPG) in olfactory bulbectomy (OBX) induced depression and anxiety in rats. The surgery was performed in 30 male rats and was recovered by keeping in socialisolation condition for the period of 14 days followed by the treatment for next 14 days. Fluoxetine (10mg/kg, p.o), HEPG (10, 30 and 100mg/kg, p.o) were administered 1 hr prior to study. Parameters as open field test, force swim test, novelty suppressed feeding, sucrose intake test were studied. At the end of study brain monoamine estimation was carried out. Extract in all three doses significantly reversed hyperactivity in open field as well as all the parameters of anxiety along with normalization of brain monoamines.